Peer-reviewed scientific articles

# Equal contribution / * shared corresponding author

  1. Olotu O, Koskenniemi A-R, Ma L, Paramonov V, Laasanen S, Louramo E, Bourgery M, Lehtiniemi T, Laasanen S, Rivero-Müller A, Löyttyniemi E, Sahlgren CM, Westermarck J, Ventelä S, Visakorpi T, Poutanen M, Vainio P, Mäkelä J-A, Kotaja N. Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth. Cell Reports. 2024. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00759-9

  2. Prabhakar N, Långbacka E, Özliseli E, Mattsson J, Mahran A, Suleymanova I, Sahlgren CM, Rosenholm JM*, Åkerfelt M*, Nees M*. Surface Modification of Mesoporous Silica Nanoparticles as a Means to Introduce Inherent Cancer-Targeting Ability in a 3D Tumor Microenvironment. Small Science. 2024. https://onlinelibrary.wiley.com/doi/full/10.1002/smsc.202400084

  3. Jouybar M#, Sleeboom JJF#, Vaezzadeh E, Sahlgren CM, den Toonder JMJ. An in vitro model of cancer invasion with heterogeneous ECM created with droplet microfluidics. Front Bioeng Biotechnol. 2023. https://pubmed.ncbi.nlm.nih.gov/38076430/

  4. Özliseli E, Sanlidag S, Süren B, Mahran A, Parikainen M, Sahlgren CM*, Rosenholm JM*. Directing cellular responses in a nanocomposite 3D matrix for tissue regeneration with nanoparticle-mediated drug delivery. Materials Today Bio. 2023. https://www.sciencedirect.com/science/article/pii/S2590006423003253

  5. Grolleman J, van Engeland NCA, Raza M, Azimi S, Conte V, Sahlgren CM#, Bouten CVC#. Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells. Scientific Reports. 2023.https://www.nature.com/articles/s41598-023-44835-8

  6. Suarez Rodriguez F#, Sanlidag S#, Sahlgren CM. Mechanical regulation of the Notch signaling pathway. Current Opinion in Cell Biology. 2023. https://www.sciencedirect.com/science/article/pii/S0955067423000935

  7. Bril M, Saberi A, Jorba I, van Turnhout MC, Sahlgren CM, Bouten CV, Schenning AP, Kurniawan NA. Shape‐Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts. Advanced Science. 2023. https://onlinelibrary.wiley.com/doi/10.1002/advs.202303136

  8. Mostert D, Grolleman J, van Turnhout MC, Groenen BGW, Conte V, Sahlgren CM, Kurniawan NA, Bouten CVC. SFAlab: image-based quantification of mechano-active ventral actin stress fibers in adherent cells. Front. Cell Dev. Biol. 2023. https://doi.org/10.3389/fcell.2023.1267822

  9. van Asten JGM, Latorre M, Karakaya C, Baaijens FPT, Sahlgren CM, Ristori T, Humphrey JD, Loerakker S. A multiscale computational model of arterial growth and remodeling including Notch signaling. Biomech Model Mechanobiol. 2023. https://doi.org/10.1007/s10237-023-01697-3.

  10. Soto Véliz D, Lin KL, Sahlgren CM. Organ-on-a-Chip Technologies for biomedical research and drug development: a focus on the vasculature. Smart Medicine. 2023. https://doi.org/10.1002/SMMD.20220030

  11. Castro‑Muñoz LJ, Vázquez Ulloa E, Sahlgren CM, Lizano M, De La Cruz-Hernández E, Contreras‑Paredes A. Modulating epigenetic modifications for cancer therapy (Review). Oncol Rep. 2023. https://doi.org/10.3892/or.2023.8496

  12. Meng Y, Sanlidag S, Jensen SA, Burnap SA, Struwe WB, Larsen AH, Feng X, Mittal S, Sansom MSP, Sahlgren CM, Handford PA. An N-glycan on the C2 domain of Jagged1 is important for Notch activation. Sci Signal. 2022. https://doi.org/10.1126/scisignal.abo3507

  13. Vázquez-Ulloa E, Lin KL, Lizano M, Sahlgren CM. Reversible and bidirectional signaling of Notch ligands. Crit Rev Biochem Mol Biol. 2022. https://doi.org/10.1080/10409238.2022.2113029

  14. Karakaya C, van Turnhout MC, Visser VL, Ristori T, Bouten CVC, Sahlgren CM, Loerakker S. Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells. Front Cell Dev Biol. 2022. https://doi.org/10.3389/fcell.2022.910503

  15. van Asten JGM#, Ristori T#, Nolan DR, Lally C, Baaijens FPT, Sahlgren CM, Loerakker S. Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension. J Mech Behav Biomed Mater. 2022. https://doi.org/10.1016/j.jmbbm.2022.105325

  16. Kałafut J, Czapiński J, Przybyszewska-Podstawka A, Czerwonka A, Odrzywolski A, Sahlgren CM, Rivero-Müller A. Optogenetic control of NOTCH1 signaling. Cell Commun Signal. 2022. https://doi.org/10.1186/s12964-022-00885-5

  17. Tiemeijer LA#, Ristori T#, Stassen OMJA, Ahlberg JJ, de Bijl JJJ, Chen CS, Bentley K, Bouten CVC, Sahlgren CM. Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting. iScience. 2022. https://doi.org/10.1016/j.isci.2022.104306

  18. Zhang S, Miyakawa A, Wickström M, Dyberg C, Louhivuori L, Varas-Godoy M, Kemppainen K, Kanatani S, Kaczynska D, Dehnisch Ellström I, Elfman L, Kronqvist P, Repo H, Mikoshiba K, Sahlgren CM, Inge Johnsen J, Uhlén P. GIT1 Protects Against Breast Cancer Growth Through Negative Regulation of Notch. Nat Commun. 2022. https://doi.org/10.1038/s41467-022-28631-y.

  19. Tiemeijer LA#, Sanlidag S#, Bouten CVC, Sahlgren CM. Engineering tissue morphogenesis: taking it up a Notch. Trends Biotechnol. 2022. https://doi.org/10.1016/j.tibtech.2022.01.007

  20. Ghafari AM, Domínguez SE, Järvinen V, Gounani Z, Schmit A, Sjöqvist M, Sahlgren CM, Salo-Ahen OMH, Kvarnström C, Torsi L, Österbacka R. In Situ Coupled Electrochemical-Goniometry as a Tool to Reveal Conformational Changes of Charged Peptides. Adv Mater Interfaces. 2021. https://doi.org/10.1002/admi.202101480

  21. Karakaya C, van Asten JGM, Ristori T, Sahlgren CM, Loerakker S. Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering. Biomech Model Mechanobiol. 2021. https://doi.org/10.1007/s10237-021-01521-w

  22. Wawruszak A, LuszczkiJ, Halasa M, Okon E, Landor S, Sahlgren CM, Rivero-Muller A*, Stepulak A*. Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22105184

  23. Landor SKJ#, Santio NM#, Eccleshall WB, Kovall RA, Koskinen PJ*, Sahlgren CM*. PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. J Biol Chem. 2021. https://doi.org/10.1016/j.jbc.2021.100593

  24. Ristori T, Sjöqvist M, Sahlgren CM. Ex vivo models to decipher the molecular mechanisms of genetic Notch cardiovascular disorders. Tissue Engineering: Part C. 2021. https://doi.org/10.1089/ten.TEC.2020.0327

  25. Prabhakar N, Belevich I, Peurla M, Heiligenstein X, Chang HC, Sahlgren C, Jokitalo E, Rosenholm JM. Cell Volume (3D) Correlative Microscopy Facilitated by Intracellular Fluorescent Nanodiamonds as Multi-Modal Probes. 2020. Nanomaterials (Basel). https://doi.org/10.3390/nano11010014

  26. Stassen O, Ristori T, Sahlgren CM. Notch in Mechanotransduction, from Molecular Mechanosensitivity to Tissue Mechanostasis. J Cell Sci. 2020. https://doi.org/10.1242/jcs.250738

  27. Sjöqvist M, Antfolk D, Suarez Rodriguez F, Sahlgren CM. From structural resilience to cell specification - Intermediate filaments as regulators of cell fate. FASEB J. 2020. https://doi.org/10.1096/fj.202001627R

  28. Paramonov V, Sahlgren CM, Rivero-Müller A, Pulliainen A. iGIST - a kinetic bioassay for pertussis toxin based on its effect on inhibitory GPCR signaling. ACS Sensors. 2020. https://doi.org/10.1021/acssensors.0c01340

  29. Paramonov VM#, Gerstenberg M#, Sahlgren CM, Lindén M, Rivero-Müller A. In vitro targetability validation of peptide-functionalized mesoporous silica nanoparticles in the presence of serum proteins. Front Chem. 2020. https://doi.org/10.3389/fchem.2020.603616

  30. Driessen R#, Zhao F#, Hofmann S, Bouten C, Sahlgren CM, Stassen O. Computational characterization of the dish-in-a-dish, a high yield culture platform for endothelial shear stress studies on the orbital shaker. Micromachines. 2020. https://doi.org/10.3390/mi11060552

  31. Özliseli E, Ṣen Karaman D, Soumyananda C, Slita A, Parikainen M, Sahlgren CM, Rosenholm JM. Rational evaluation of human serum albumin coated mesoporous silica nanoparticles for xenogenic-free stem cell therapies. Colloids Surf A Physicochem Eng Asp. 2020. https://doi.org/10.1016/j.colsurfa.2020.124945

  32. Tanaka N, Kanatani S, Kaczynska D, Fukumoto K, Louhivuori L, Mizutani T, Kopper O, Kronqvist P, Robertson S, Lindh C, Kis L, Pronk R, Niwa N, Matsumoto K, Oya M, Miyakawa A, Falk A, Hartman J, Sahlgren CM, Clevers H, Uhlén P. Three-dimensional Single-Cell Imaging for the Analysis of RNA and Protein Expression in Intact Tumour Biopsies. Nat Biomed Eng. 2020. https://doi.org/10.1038/s41551-020-0576-z

  33. Ristori T, Stassen OMJA, Sahlgren CM, Loerakker S. Lateral Induction Limits the Impact of Cell Connectivity on Notch Signaling in Arterial Walls. Int J Numer Method Biomed Eng. 2020. https://doi.org/10.1002/cnm.3323

  34. Niemelä E, Desai D, Niemi R, Doroszko M, Özliseli E, Kemppainen K, Rahman NA, Sahlgren CM, Törnquist K, Eriksson JE, Rosenholm JM. Nanoparticles Carrying Fingolimod and Methotrexate Enables Targeted Induction of Apoptosis and Immobilization of Invasive Thyroid Cancer. Eur J Pharm Biopharm. 2020. https://doi.org/10.1016/j.ejpb.2019.12.015

  35. Wilhelmsson U, Lebkuechner I, Leke R, Marasek P, Yang X, Antfolk D, Chen M, Mohseni P, Lasič E, Bobnar ST, Stenovec M, Zorec R, Nagy A, Sahlgren CM, Pekna M, Pekny M. Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells. Cereb Cortex. 2019. https://doi.org/10.1093/cercor/bhy284

  36. van Engeland NCA#, Suarez Rodriguez F#, Rivero-Müller A, Ristori T, Duran CL, Stassen OMJA, Antfolk D, Driessen RCH, Ruohonen S, Ruohonen ST, Nuutinen S, Savontaus E, Loerakker S, Bayless KJ, Sjöqvist M, Bouten CVC, Eriksson JE, Sahlgren CM. Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress. Sci Rep. 2019. https://doi.org/10.1038/s41598-019-48218-w

  37. Putti M, de Jong SMJ, Stassen OMJA, Sahlgren CM, Dankers PYW. A Supramolecular Platform for the Introduction of Fc-Fusion Bioactive Proteins on Biomaterial Surfaces. ACS Appl Polym Mater. 2019. https://doi:10.1021/acsapm.9b00334

  38. Antfolk D, Antila C, Kemppainen K, Landor SK, Sahlgren CM. Decoding the PTM-switchboard of Notch. Biochim Biophys Acta Mol Cell Res. 2019. https://doi.org/10.1016/j.bbamcr.2019.07.002

  39. Putti M, Stassen OMJA, Schotman MJG, Sahlgren CM, Dankers PYW. Influence of the Assembly State on the Functionality of a Supramolecular Jagged1-Mimicking Peptide Additive. ACS Omega. 2019. https://doi.org/10.1021/acsomega.9b00869

  40. Driessen RCH, Stassen OMJA, Sjöqvist M, Suarez Rodriguez F, Grolleman J, Bouten CVC, Sahlgren CM. Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1. Integr Biol (Camb). 2018. https://doi.org/10.1039/c8ib00036k

  41. Mutvei AP, Landor SK, Fox R, Braune EB, Tsoi YL, Phoon YP, Sahlgren CM, Hartman J, Bergh J, Jin S, Lendahl U. Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types. Oncogene. 2018. https://doi.org/10.1038/s41388-018-0400-3

  42. Sleeboom JJF, Toonder JMJD, Sahlgren CM. MDA-MB-231 Breast Cancer Cells and Their CSC Population Migrate Towards Low Oxygen in a Microfluidic Gradient Device. Int J Mol Sci. 2018. https://doi.org/10.3390/ijms19103047

  43. Quirós-Solano WF, Gaio N, Stassen OMJA, Arik YB, Silvestri C, Van Engeland NCA, Van der Meer A, Passier R, Sahlgren CM, Bouten CVC, van den Berg A, Dekker R, Sarro PM. Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips. Sci Rep. 2018. https://doi.org/10.1038/s41598-018-31912-6

  44. Paramonov VM, Desai D, Kettiger H, Mamaeva V, Rosenholm JM, Sahlgren CM, Rivero-Müller A. Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home? Nanotheranostics. 2018. https://doi.org/10.7150/ntno.23826

  45. van Engeland NCA, Pollet AMAO, den Toonder JMJ, Bouten CVC, Stassen OMJA, Sahlgren CM. A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab Chip. 2018. https://doi.org/10.1039/c8lc00286j

  46. Tiemeijer LA, Frimat JP, Stassen OMJA, Bouten CVC, Sahlgren CM. Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro. Sci Rep. 2018. https://doi.org/10.1038/s41598-018-24646-y

  47. Loerakker S*, Stassen OMJA, Ter Huurne FM, Boareto M, Bouten CVC, Sahlgren CM*. Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis. Proc Natl Acad Sci U S A. 2018. https://doi.org/10.1073/pnas.1715277115

  48. Tanaka N, Kaczynska D, Kanatani S, Sahlgren CM, Mitura P, Stepulak A, Miyakawa A, Wiklund P, Uhlén P. Mapping of the three-dimensional lymphatic microvasculature in bladder tumours using light-sheet microscopy. Br J Cancer. 2018. https://doi.org/10.1038/s41416-018-0016-y

  49. Sleeboom JJF, Eslami Amirabadi H, Nair P, Sahlgren CM, den Toonder JMJ. Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches. Dis Model Mech. 2018. https://doi.org/10.1242/dmm.033100

  50. Antila CJM, Rraklli V, Blomster HA, Dahlström KM, Salminen TA, Holmberg J, Sistonen L, Sahlgren CM. Sumoylation of Notch1 represses its target gene expression during cell stress. Cell Death Differ. 2018. https://doi.org/10.1038/s41418-017-0002-6

  51. Sahlgren CM, Meinander A, Zhang H, Cheng F, Preis M, Xu C, Salminen TA, Toivola D, Abankwa D, Rosling A, Karaman DŞ, Salo-Ahen OMH, Österbacka R, Eriksson JE, Willför S, Petre I, Peltonen J, Leino R, Johnson M, Rosenholm J, Sandler N. Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Adv Healthc Mater. 2017. https://doi.org/10.1002/adhm.201700258

  52. Tanaka N, Kanatani S, Tomer R, Sahlgren CM, Kronqvist P, Kaczynska D, Louhivuori L, Kis L, Lindh C, Mitura P, Stepulak A, Corvigno S, Hartman J, Micke P, Mezheyeuski A, Strell C, Carlson JW, Fernández Moro C, Dahlstrand H, Östman A, Matsumoto K, Wiklund P, Oya M, Miyakawa A, Deisseroth K, Uhlén P. Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity. Nat Biomed Eng. 2017. https://doi.org/10.1038/s41551-017-0139-0

  53. Mauretti A, Rossi F, Bax NAM, Miano C, Miraldi F, Goumans MJ, Messina E, Giacomello A, Bouten CVC, Sahlgren CM. Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells. MRS Commun. 2017. https://doi.org/10.1557/mrc.2017.82

  54. Paatero I, Casals E, Niemi R, Özliseli E, Rosenholm JM, Sahlgren CM. Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes. Sci Rep. 2017. https://doi.org/10.1038/s41598-017-09312-z

  55. Antfolk D, Sjöqvist M, Cheng F, Isoniemi K, Duran CL, Rivero-Muller A, Antila C, Niemi R, Landor S, Bouten CVC, Bayless KJ, Eriksson JE, Sahlgren CM. Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. Proc Natl Acad Sci U S A. 2017. https://doi.org/10.1073/pnas.1703057114

  56. Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor SK, Stenvall CA, Fortelius LE, Bergström LK, Sahlgren CM*, Toivola DM*. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ. 2017. https://doi.org/10.1038/cdd.2017.28

  57. Mauretti A, Spaans S, Bax NAM, Sahlgren CM, Bouten CVC. Cardiac Progenitor Cells and the Interplay with Their Microenvironment. Stem Cells Int. 2017. https://doi.org/10.1038/cdd.2017.28

  58. Mauretti A, Bax NA, van Marion MH, Goumans MJ, Sahlgren CM, Bouten CV. Cardiomyocyte progenitor cell mechanoresponse unrevealed: strain avoidance and mechanosome development. Integr Biol (Camb). 2016. https://doi.org/10.1039/c6ib00117c

  59. Baghirov H, Karaman D, Viitala T, Duchanoy A, Lou YR, Mamaeva V, Pryazhnikov E, Khiroug L, de Lange Davies C, Sahlgren CM*, Rosenholm JM*. Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier. PLoS One. 2016. https://doi.org/10.1371/journal.pone.0160705

  60. Santio NM, Landor SK, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi SY, Corthals G, Varjosalo M, Manoharan GB, Uri A, Lendahl U, Sahlgren CM*, Koskinen PJ*. Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. Oncotarget. 2016. https://doi.org/10.18632/oncotarget.9215

  61. Braune EB, Tsoi YL, Phoon YP, Landor S, Silva Cascales H, Ramsköld D, Deng Q, Lindqvist A, Lian X, Sahlgren CM, Jin SB, Lendahl U. Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells. Stem Cell Reports. 2016. https://doi.org/10.1016/j.stemcr.2016.03.004

  62. Mamaeva V, Niemi R, Beck M, Özliseli E, Desai D, Landor S, Gronroos T, Kronqvist P, Pettersen IK, McCormack E, Rosenholm JM, Linden M, Sahlgren CM. Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors. Mol Ther. 2016. https://doi.org/10.1038/mt.2016.42

  63. Rosenholm JM, Gulin-Sarfraz T, Mamaeva V, Niemi R, Özliseli E, Desai D, Antfolk D, von Haartman E, Lindberg D, Prabhakar N, Näreoja T, Sahlgren CM. Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo. Small. 2016. https://doi.org/10.1002/smll.201503392

  64. Rosenholm JM, Zhang J, Linden M, Sahlgren CM. Mesoporous silica nanoparticles in tissue engineering – perspective. Nanomedicine (Lond). 2016. https://doi.org/10.2217/nnm.15.212

  65. Desai D, Prabhakar N, Mamaeva V, Karaman DŞ, Lähdeniemi IA, Sahlgren CM*, Rosenholm JM*, Toivola DM*. Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles. Int J Nanomedicine. 2016. https://doi.org/10.2147/IJN.S94013

  66. Paramonov VM, Mamaeva V, Sahlgren CM, Rivero-Müller A. Genetically-encoded tools for cAMP probing and modulation in living systems. Front Pharmacol. 2015. https://doi.org/10.3389/fphar.2015.00196

  67. Shokry H, Vanamo U, Wiltschka O, Niinimäki J, Lerche M, Levon K, Linden M, Sahlgren CM. Mesoporous silica particle-PLA-PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization. Nanoscale. 2015. https://doi.org/10.1039/c5nr03983e

  68. Chivukula IV, Ramsköld D, Storvall H, Anderberg C, Jin S, Mamaeva V, Sahlgren CM, Pietras K, Sandberg R, Lendahl U. Decoding breast cancer tissue-stroma interactions using species-specific sequencing. Breast Cancer Res. 2015. https://doi.org/10.1186/s13058-015-0616-x

  69. Rosenholm JM, Korpi RM, Lammentausta E, Lehtonen S, Lehenkari P, Niemi R, Xiao W, Zhang J, Råtts N, Gu H, Sahlgren CM*, Sequeiros RB*. Novel, Fast-Processed Crystalline and Amorphous Manganese Oxide Nanoparticles for Stem Cell Labeling. Inorg Chem Front. 2015. https://doi.org/10.1039/C5QI00033E

  70. Wittig R*, Rosenholm JM, von Haartman E, Hemming J, Genze F, Bergman L, Simmet T, Lindén M, Sahlgren CM*. Active targeting of mesoporous silica drug carriers enhances γ-secretase inhibitor efficacy in an in vivo model for breast cancer. Nanomedicine (Lond). 2014. https://doi.org/10.2217/nnm.13.62

  71. Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren CM. PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res. 2014. https://doi.org/10.1038/cr.2014.34

  72. Wiltschka O, Böcking D, Brenner R, Sahlgren CM, Lindén M. Preparation, characterization, and preliminary biocompatibility evaluation of particulate spin-coated mesoporous silica films. Microporous Mesoporous Mater. 2014. https://doi.org/10.1016/j.micromeso.2014.01.006

  73. Böcking D, Wiltschka O, Niinimäki J, Shokry H, Brenner R, Lindén M, Sahlgren CM. Mesoporous silica nanoparticle-based substrates for cell directed delivery of Notch signalling modulators to control myoblast differentiation. Nanoscale. 2014. https://doi.org/10.1039/c3nr04022d

  74. Gulin-Sarfraz TJ, Zhang J, Desai D, Teuho J, Sarfraz J, Jiang H, Zhang C, Sahlgren CM, Lindén M, Gu H, Rosenholm JM. Combination of magnetic field and surface functionalization for reaching synergistic effects in cellular labeling by magnetic core-shell nanospheres. Biomater Sci. 2014. https://doi.org/10.1039/C4BM00221K

  75. Jin S, Mutvei AP, Chivukula IV, Andersson ER, Ramsköld D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling P, Mpindi JP, Kallioniemi O, Screpanti I, Poellinger L, Sahlgren CM, Lendahl U. Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ. Oncogene. 2013. https://doi.org/10.1038/onc.2012.517

  76. Prabhakar N, Näreoja T, von Haartman E, Karaman DŞ, Jiang H, Koho S, Dolenko TA, Hänninen PE, Vlasov DI, Ralchenko VG, Hosomi S, Vlasov II, Sahlgren CM, Rosenholm JM. Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application. Nanoscale. 2013. https://doi.org/10.1039/c3nr33926b

  77. Mamaeva V, Sahlgren CM*, Lindén M*. Mesoporous silica nanoparticles in medicine – recent advances. Adv Drug Deliv Rev. 2013. https://doi.org/10.1016/j.addr.2012.07.018

  78. Wilhelmsson U, Faiz M, de Pablo Y, Sjöqvist M, Andersson D, Widestrand A, Potokar M, Stenovec M, Smith PL, Shinjyo N, Pekny T, Zorec R, Ståhlberg A, Pekna M, Sahlgren CM, Pekny M. Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway. Stem Cells. 2012. https://doi.org/10.1002/stem.1196

  79. Karaman DS, Desai D, Senthilkumar R, Johansson EM, Råtts N, Odén M, Eriksson JE, Sahlgren CM, Toivola DM, Rosenholm JM. Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization. Nanoscale Res Lett. 2012. https://doi.org/10.1186/1556-276X-7-358

  80. Rosenholm JM, Mamaeva V, Sahlgren CM*, Lindén M*. Nanoparticles in targeted cancer therapy: mesoporous silica nanoparticles entering preclinical development stage. Nanomedicine (Lond). 2012. https://doi.org/10.2217/nnm.11.166

  81. Landor SK, Mutvei AP, Mamaeva V, Jin S, Busk M, Borra R, Grönroos TJ, Kronqvist P, Lendahl U, Sahlgren CM. Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms. Proc Natl Acad Sci U S A. 2011. https://doi.org/10.1073/pnas.1104943108

  82. Mamaeva V, Rosenholm JM, Bate-Eya LT, Bergman L, Peuhu E, Duchanoy A, Fortelius LE, Landor S, Toivola DM, Lindén M, Sahlgren CM. Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer. Mol Ther. 2011. https://doi.org/10.1038/mt.2011.105

  83. Rosenholm JM, Sahlgren CM*, Lindén M*. Multifunctional mesoporous silica nanoparticles for combined therapeutic, diagnostic and targeted action in cancer treatment. Curr Drug Targets. 2011. https://doi.org/10.2174/138945011795906624

  84. Pallari HM, Lindqvist J, Torvaldson E, Ferraris SE, He T, Sahlgren CM, Eriksson JE. Nestin as a regulator of Cdk5 in differentiating myoblasts. Mol Biol Cell. 2011. https://doi.org/10.1091/mbc.E10-07-0568

  85. Das D, Lanner F, Main H, Andersson ER, Bergmann O, Sahlgren CM, Heldring N, Hermanson O, Hansson EM, Lendahl U. Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells. Dev Biol. 2010. https://doi.org/10.1016/j.ydbio.2010.09.018

  86. Rosenholm JM, Sahlgren CM*, Lindén M*. Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles--opportunities & challenges. Nanoscale. 2010. https://doi.org/10.1039/c0nr00156b

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